Xi Li Selected Research

PDK1 inhibitor 9za

1/2020

A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells.

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Xi Li Research Topics

Disease

143	Neoplasms (Cancer) 06/2022 - 09/2002
37	Infections 05/2022 - 08/2007
37	Inflammation (Inflammations) 03/2022 - 03/2007
37	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2022 - 06/2004
26	Breast Neoplasms (Breast Cancer) 04/2022 - 06/2006
22	Myocardial Infarction 12/2021 - 06/2013
21	Lung Neoplasms (Lung Cancer) 09/2021 - 05/2005
20	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 05/2011
18	Neoplasm Metastasis (Metastasis) 09/2022 - 06/2006
17	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 02/2010
15	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 06/2010
14	Wounds and Injuries (Trauma) 01/2021 - 12/2014
12	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2013
11	Obesity 07/2022 - 09/2006
11	Insulin Resistance 07/2022 - 06/2006
11	Fibrosis (Cirrhosis) 01/2022 - 11/2016
11	Adenocarcinoma of Lung 01/2022 - 01/2014
11	Ischemic Stroke 01/2021 - 08/2010
11	Carcinoma (Carcinomatosis) 07/2020 - 04/2002
10	Body Weight (Weight, Body) 01/2022 - 05/2014
10	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 05/2006
10	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 09/2006
10	Carcinogenesis 01/2020 - 10/2007
9	Hypoxia (Hypoxemia) 05/2022 - 09/2011
9	Non-alcoholic Fatty Liver Disease 01/2022 - 12/2015
9	Liver Diseases (Liver Disease) 01/2021 - 11/2011
9	Type 2 Diabetes Mellitus (MODY) 01/2021 - 08/2014
8	Hypertension (High Blood Pressure) 12/2021 - 04/2005
8	Melanoma (Melanoma, Malignant) 09/2021 - 06/2013
7	Colonic Neoplasms (Colon Cancer) 01/2021 - 08/2007
7	Necrosis 10/2020 - 05/2006
6	Colorectal Neoplasms (Colorectal Cancer) 09/2022 - 04/2017
6	Ischemia 07/2022 - 03/2005
6	Bacterial Infections (Bacterial Infection) 05/2022 - 02/2010
6	Reperfusion Injury 11/2021 - 03/2005
6	Diarrhea 01/2021 - 05/2011
6	Stroke (Strokes) 01/2021 - 08/2010
6	Dementia (Dementias) 01/2020 - 10/2006
6	Coronary Disease (Coronary Heart Disease) 01/2019 - 05/2011
5	Aortic Valve Stenosis (Aortic Stenosis) 06/2022 - 01/2020
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2016
5	COVID-19 01/2022 - 01/2020
5	Pancreatic Neoplasms (Pancreatic Cancer) 11/2021 - 05/2012
5	Stomach Neoplasms (Stomach Cancer) 04/2021 - 05/2017
5	ST Elevation Myocardial Infarction 01/2021 - 02/2016
5	Sepsis (Septicemia) 01/2021 - 06/2012
5	Cognitive Dysfunction 01/2021 - 05/2014

Drug/Important Bio-Agent (IBA)

46	Proteins (Proteins, Gene)FDA Link 07/2022 - 09/2006
33	Pharmaceutical PreparationsIBA 12/2021 - 12/2006
28	Biomarkers (Surrogate Marker)IBA 04/2022 - 01/2015
24	MicroRNAs (MicroRNA)IBA 05/2022 - 03/2014
17	PlatinumIBA 03/2022 - 06/2004
17	Messenger RNA (mRNA)IBA 01/2021 - 06/2006
16	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 08/2007
15	Long Noncoding RNAIBA 01/2022 - 06/2016
15	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2003
14	EnzymesIBA 01/2022 - 12/2005
14	ErbB Receptors (EGF Receptor)IBA 01/2022 - 11/2013
13	LigandsIBA 01/2022 - 04/2011
10	Biological ProductsIBA 01/2022 - 07/2012
10	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2021 - 09/2011
10	AntigensIBA 09/2021 - 05/2010
9	Therapeutic UsesIBA 01/2022 - 01/2009
9	RNA (Ribonucleic Acid)IBA 01/2022 - 09/2015
9	Indicators and Reagents (Reagents)IBA 11/2021 - 07/2011
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 06/2006
9	Amyloid (Amyloid Fibrils)IBA 01/2020 - 08/2014
9	Cisplatin (Platino)FDA LinkGeneric 10/2019 - 06/2004
8	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2020 - 02/2011
7	Interleukin-6 (Interleukin 6)IBA 01/2022 - 10/2009
7	CytokinesIBA 01/2022 - 05/2011
7	VaccinesIBA 11/2021 - 01/2009
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 03/2007
7	Peptides (Polypeptides)IBA 09/2021 - 02/2010
7	ginsenoside Rg1IBA 10/2020 - 10/2006
7	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 08/2010
7	EndostatinsIBA 02/2005 - 04/2002
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2014
6	icotinibIBA 01/2022 - 08/2012
6	Tyrosine Kinase InhibitorsIBA 09/2021 - 11/2013
6	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2015
6	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 02/2015
6	Liposomes (Liposome)IBA 01/2019 - 02/2003
6	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 05/2006
5	GoldIBA 04/2022 - 04/2011
5	Estrogens (Estrogen)FDA Link 03/2022 - 12/2015
5	InterferonsIBA 01/2022 - 08/2013
5	Alanine Transaminase (SGPT)IBA 12/2021 - 05/2006
5	Aspartate Aminotransferases (Aspartate Transaminase)IBA 12/2021 - 05/2006

Therapy/Procedure

83	Therapeutics 09/2022 - 11/2002
44	Drug Therapy (Chemotherapy) 09/2022 - 06/2004
12	Immunotherapy 12/2021 - 07/2010
11	Secondary Prevention 01/2020 - 08/2010
7	Transcatheter Aortic Valve Replacement 11/2022 - 01/2020
7	Percutaneous Coronary Intervention 01/2020 - 03/2014
6	Radiotherapy 01/2022 - 09/2014
6	Length of Stay 01/2021 - 04/2010
6	Liver Transplantation 02/2016 - 08/2007
5	Transplantation 01/2022 - 08/2007
5	Chinese Traditional Medicine (Traditional Chinese Medicine) 05/2021 - 10/2006